Chitosan-Glycine Cross-Linked Microspheres for Controlled Release of Isoniazid

Abstract

Semi-interpenetrating polymer network microspheres of chitosan with glycine have been prepared for encapsulation and controlled release of isoniazid (INH) as a model drug. The method involved the exposure of microspheres to the vapor of cross-linking agent to effect the cross-linking under mild conditions. The swelling behavior, hydrolytic degradation and loading capacity of microspheres for INH have been investigated. The prepared microspheres have shown 96% drug loading capacity, which suggested that these semi-interpenetrating polymer network microspheres are suitable to controlled release of drugs in an oral sustained delivery system.

Cite this Article

K. C. Gupta, M. N. V. Ravikumar, Fawzi Habeeb Jabrail. Chitosan-Glycine Cross-Linked microspheres for controlled release of isoniazid. Journal of Modern Chemistry & Chemical Technology. 2015; 6(3): 7–12p.