A Comprehensive Review on Buccal Drug Delivery System

Abstract

Buccal delivery involves the running of the desired drug through the buccal mucosal membrane lining of the oral cavity. The buccal region of the oral cavity is a striking target for administration of the drug of choice because it offers some discrete advantages over all other routes. However, the mucosal lining of the oral cavity drugs which undergo rigorous firstpass metabolism, for those drugs, buccal route are excellent. Buccal drug delivery is a potential area for continued research with the aim of systemic delivery of orally ineffective drugs as well as a feasible and striking alternative for non-invasive delivery of potent peptide and protein drug molecules. The buccal formulations are sited in the mouth between the upper gingival (gums) and cheek to treat local and systemic conditions. Bioadhesion is defined as the affirm in which two bodies’ one or both of adherents are of a biological nature and are held mutually for extended periods of time by interfacial forces. A bioadhesive can therefore be distinct as a substance, which has an ability to interact with biological materials, and is capable of being retained on the biological substrate for a period of time. However, the need for safe and effective buccal permeation/absorption enhancers is a vital component for a prospective future in the area of buccal drug delivery. 

Keywords: Buccal drug delivery, bioadhesion, first pass metabolism, mucoadhesion 

Ipshita Sarkar, Jaimini Gandhi, Pranav Shah et al. A Comprehensive Review on Buccal Drug Delivery System. Research and Reviews: A Journal of Pharmaceutical Science. 2017; 8(2):   20–32p.