Toxic Potential of Carbaryl on Reproductive and Fertility Parameter in Male Wister Albino Rats

Abstract

Abstract

This study aims to evaluate the adverse effect of carbaryl on reproductive system of male Wister albino rats. Adult male Wister albino rats were orally administered with 50, 100 and 150 mg/kg body weight of carbaryl for 90 days. Animals from each group were sacrificed after the study period. Sperm count, sperm motility, antioxidant assay (SOD, CAT, LPO, and protein carbonyl), Hormones assay histological analysis and fertility parameters were performed on each rat. Fertility was significantly reduced in these rats. The body weight gain was significantly lower and the sperm count and motility were significantly decreased in carbaryl-administered males. The serum level of testosterone, follicle-stimulating hormone and luteinizing hormone were also significantly reduced. The protein carbonyl and antioxidant enzyme activities were decreased. The histological lesion also increased when the doses were increased. The results clearly demonstrate the adverse effect of carbaryl pesticides on fertility and reproduction in male rats.

Keywords: Carbaryl, testicular toxicity, testosterone and pesticide

Cite this Article

Sundararajan Madhumathi, Ganapathy Murugan Alagu Lakshmanan. Toxic potential of carbaryl on reproductive and fertility parameter in male Wister albino rats. Research and Reviews: Journal of Toxicology (RRJoT). 2015; 5(2): 1–6p.