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In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-inflammatory Agents

Ruchika Goyal, Sandeep Jain

Abstract


Abstract

Curcumin is a polyphenolic compound well known for its anti-inflammatory properties. The aim of the study was to design some novel curcumin derivatives that are water soluble as well as good anti-inflammatory agents with fewer side effects. In silico study was performed on the proteins by using three softwares iGEMDOCK, AutoDOCK, AutoDOCKVina as dual inhibitors for both COX-1 and COX-2. The result gives us theoretical contribution for understanding the ligand-protein interactions at molecular level. Furthermore, we could also develop some novel curcumin analogues that possess good anti-inflammatory activity, water solubility and lower toxicity.

Keywords: Curcumin, inflammation, docking, COX-1, COX-2

Cite this Article

Ruchika Goyal, Sandeep Jain. In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-Inflammatory Agents. Research & Reviews: A Journal of Bioinformatics. 2017; 4(1): 25–30p.


 


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