Role of Models in Predicting Toxicity Criteria against Arsenic Toxicity Test Exposed to Therapon Jarbua (Forsskal, 1775)
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acute-to-chronic estimation, crescent perch, DEBtox, killing rate, no-effect concentrationResumé
Prediction of safe concentration, no-effect concentration for reduced animal usage in chronic toxicity test was attempted as well as to create a toxicity criteria limit for arsenic using Therapon jarbua in static renewal acute toxicity test. The LC50 value derived was 3.95 (3.43–4.58) mg/L arsenic. The derived LC50 was applied for prediction of safe concentration leading to a value of 39.5 µg/L. The raw survival and mortality data was fed in acute to chronic estimation software, the no-effect concentration predicted through accelerated life testing was 27, 15 and 10 µg/L for 30, 60 and 90 days, 92 µg/L was predicted by multifactor probit analysis and 43 µg/L by linear regression analysis. The DEBtox software predicted a no-effect concentration of 44 µg/L with a killing rate of 69 µg/L/day. Hence, predicted toxicity limits and criteria seem to be very essential for sustainable laboratory bioassays with reduced test organisms. Keywords: Acute-to-chronic estimation, crescent perch, DEBtox, killing rate, no-effect concentration
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