Hydrotropes as Effective Reaction Media for the Synthesis of Carbamazepine

Autori

  • Jagannath J. Kadam
  • Ajay Patil
  • Vijay G. Bhawe
  • Manohar V. Lokhande DEPARTMENT OF CHEMISTRY SATHAYE COLLEGE, VILE PARLE EAST MUMBAI-400057 INDIA

Parole chiave:

Hydrotropes, xylene sulfonic acid (XSA), cumene sulfonic acid (CSA), (n-BBSA), n-Butyl benzene sulfonic acid (n-BBSA), isobutyl benzene sulfonic acid (I-BBSA), 1HNMR, IR.

Abstract

 The paper describes the synthesis of Carbamazepine. It is used as an anticonvulsant and antiemetic agent. It is also used in the treatment of pain associated with trigeminal neuralgia, often within 24 to 48 hr. The synthesis of Carbamazepine was carried out using four different hydrotropes. The effects of hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations were studied.Keywords: Hydrotropes, xylene sulfonic acid (XSA), cumene sulfonic acid (CSA), (n-BBSA): n-Butyl benzene sulfonic acid (n-BBSA), isobutyl benzene sulfonic acid (I-BBSA), 1HNMR, IR.

Biografia autore

  • Manohar V. Lokhande, DEPARTMENT OF CHEMISTRY SATHAYE COLLEGE, VILE PARLE EAST MUMBAI-400057 INDIA
    ASSIATANT PROFESSOR IN CHEMSITRY

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Pubblicato

2012-08-16

Fascicolo

V. 3 N. 2 (2012)

Sezione

Review Articles

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