Hydrotropes as Effective Reaction Media for the Synthesis of Carbamazepine

Autoři

  • Jagannath J. Kadam
  • Ajay Patil
  • Vijay G. Bhawe
  • Manohar V. Lokhande DEPARTMENT OF CHEMISTRY SATHAYE COLLEGE, VILE PARLE EAST MUMBAI-400057 INDIA

Klíčová slova:

Hydrotropes, xylene sulfonic acid (XSA), cumene sulfonic acid (CSA), (n-BBSA), n-Butyl benzene sulfonic acid (n-BBSA), isobutyl benzene sulfonic acid (I-BBSA), 1HNMR, IR.

Abstrakt

 The paper describes the synthesis of Carbamazepine. It is used as an anticonvulsant and antiemetic agent. It is also used in the treatment of pain associated with trigeminal neuralgia, often within 24 to 48 hr. The synthesis of Carbamazepine was carried out using four different hydrotropes. The effects of hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations were studied.Keywords: Hydrotropes, xylene sulfonic acid (XSA), cumene sulfonic acid (CSA), (n-BBSA): n-Butyl benzene sulfonic acid (n-BBSA), isobutyl benzene sulfonic acid (I-BBSA), 1HNMR, IR.

Biografie autora

  • Manohar V. Lokhande, DEPARTMENT OF CHEMISTRY SATHAYE COLLEGE, VILE PARLE EAST MUMBAI-400057 INDIA
    ASSIATANT PROFESSOR IN CHEMSITRY

Stažení

Publikováno

2012-08-16

Číslo

Vol 3 No 2 (2012)

Sekce

Review Articles

Licence

Declaration and Copyright Transfer Form

(to be completed by authors)

 

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. _______________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.