Chitosan-Glycine Cross-Linked Microspheres for Controlled Release of Isoniazid

作者

  • K. C. Gupta
  • M NV Ravikumar Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India
  • Fawzi Habeeb Jabrail Polymer Research Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India

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Polymer##common.commaListSeparator## microspheres##common.commaListSeparator## glycine##common.commaListSeparator## cross-linking##common.commaListSeparator## drugs

摘要

Semi-interpenetrating polymer network microspheres of chitosan with glycine have been prepared for encapsulation and controlled release of isoniazid (INH) as a model drug. The method involved the exposure of microspheres to the vapor of cross-linking agent to effect the cross-linking under mild conditions. The swelling behavior, hydrolytic degradation and loading capacity of microspheres for INH have been investigated. The prepared microspheres have shown 96% drug loading capacity, which suggested that these semi-interpenetrating polymer network microspheres are suitable to controlled release of drugs in an oral sustained delivery system.Cite this Article K. C. Gupta, M. N. V. Ravikumar, Fawzi Habeeb Jabrail. Chitosan-Glycine Cross-Linked microspheres for controlled release of isoniazid. Journal of Modern Chemistry & Chemical Technology. 2015; 6(3): 7–12p.

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出版日期

2015-12-21

期號

卷 6 期 3 (2015)

分類

Research Articles

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