¬¬¬Lycopene Protects Testes and Epididymal Sperm in BPA Exposed Adult Sprague-Dawley Rats

Autores/as

  • P. Tamilselvan
  • K. Bharathiraja
  • S. Vijayaprakash
  • M.P. Balasubramanian

Palabras clave:

bisphenol A, lycopene, oxidative stress, reproductive organs, sperm character

Resumen

Bisphenol A (BPA) is ubiquitous and persistent environmental contaminant.  Previous studies proved that BPA disrupt hypothalamic–pituitary–gonadal axis and oxidative balance. Numerous studies have clearly been reported that oxidative stress leads to male infertility by affecting testes and spermatozoa. On the other hand, lycopene has beneficial role on testes and spermatozoa by reducing the oxidative stress. Therefore, this study was conducted to delineate the protective role of lycopene by acting against BPA induced infertility and oxidative imbalance. Hence, the animal was divided into 4 groups with 6 animals in each group. Group I (vehicle control), II (BPA exposed), III (BPA exposure+Lycopene treatment) and IV (Lycopene treatment) and treated with suitable drugs for 30 days. After 30 days, the animals were dislocated, collected blood, testes and cauda epididymis. Hormones (LH, FSH, and Testosterone) levels were assayed in blood sample, antioxidants (SOD, CAT, GPx,GR activities and vitamin C, vitamin E,  levels) status, oxidative stress parameters (LPO and H2O2) were analyzed in testes and Sperm count and motility were analyzed by using cauda epididymal sperm. In the present study, hormone levels, antioxidants, sperm count and motility were significantly reduced in BPA exposed rats where as oxidative stress parameters were elevated. In conclusion, BPA-induced oxidative stress and hormonal alteration lead to male infertility. Because of antioxidant potential of lycopene, ameliorates the changes which are induced by BPA.

Descargas

Publicado

2013-04-23

Número

Vol. 1 Núm. 1 (2013): SPECIAL ISSUE

Sección

Research Articles

Licencia

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.