The Mechanism of Regulation of Chemolithotrophic Sulfur Oxidation in Pseudaminobacter salicylatoxidans KCT001

Autoři

  • Sukhendu Mandal Waksman Institute, Rutgers University New Jersey, USA
  • Wriddhiman Ghosh

Klíčová slova:

Expression/regulation/sox operon/sulfur-chemolithotrophy

Abstrakt

Although the mode of repression of the sulfur oxidation (sox) operon has been elucidated in recent times the mechanism of its derepression is not yet known. Here we propose a comprehensive mechanism of sox gene expression by envisaging redox modulation of soxR as the key to the repression as well as derepression of sox-mediated thiosulfate oxidation Pseudaminobacter salicylatoxidans KCT001. While soxR, rendered to its reduced state by the action of soxS, keeps the sox system repressed, the oxidized species of the same protein is responsible for switching the system on. When thiosulfate appears in the medium, the basal amount of catalytic sox gene products, always present in the cells, convert 5–10% of supplied thiosulfate to sulfate without the participation of newly synthesized sox proteins. Sulfate produced from this basal level oxidation of thiosulfate can render the oxidation of soxR and thereby get converted to thiosulfate. This may be re-exported to the periplasm by the transmembrane protein soxT. This short cycle of conversion of thiosulfate to sulfate thus induces the expression of the sox genes.

Biografie autora

  • Sukhendu Mandal, Waksman Institute, Rutgers University New Jersey, USA
    Research AssociateDepartment of MicrobiologyRutgers University

Stažení

Publikováno

2012-05-23

Číslo

Vol 2 No 1 (2012)

Sekce

Case Study

Licence

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.