A Clinical Correlation Made Between Opioid-induced Hyperalgesia and Hyperkatifeia with Brain Alterations Induced by Long-term Prescription Opioid Use

Autor/innen

  • John Grandy Whitestone Consulting LLC subcontractor of the Department of Defense- Fort Drum New York North Country Urgent Care, Watertown, New York.

Schlagwörter:

amygdala, POATS, opioid-induced neuron atrophy, intracellular messenger phosphokinase C, and NMDA receptors.

Abstract

The goal of this article is to establish a correlation between the clinical manifestations of opioid-induced hyperalgesia and hyperkatifeia with the morphological and functional connectivity changes seen in the human brain that can be caused by long-term prescription opioid use.  This will be accomplished by reviewing the imaging results found in a small but unique study that demonstrated morphological and functional connectivity changes in long-term prescription opioid users.  The primary regions that were affected were the amygdala and the white matter tracts connected to it.  Therefore, by reviewing the known functions of the amygdala and the white matter tracts- uncinate fasciculus, stria terminalis, and ventral amygdalofugal- and then doing a comparative analysis between the signs and symptoms of the clinical syndromes of opioid-induced hyperalgesia and hyperkatifeia a very obvious correlation has been recognized.  

Autor/innen-Biografie

  • John Grandy, Whitestone Consulting LLC subcontractor of the Department of Defense- Fort Drum New York North Country Urgent Care, Watertown, New York.
    I have been a physician associate for 7 years in the feilds of psychiatry, internal medicine, primary care, and urgent care.

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Veröffentlicht

2012-08-24

Ausgabe

Bd. 2 Nr. 2 (2012)

Rubrik

Review Articles

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