Preparation and Characterization of Microwave-assisted Candesartan Cilexetil Solid Dispersions
Parole chiave:
Microwave, candesartan cilexetil, solubility, dissolution rateAbstract
The aim of the present study was to enhance the solubility & dissolution rate of a poorly soluble, BCS class II drug candesartan cilexetil (CC), using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000 & hydroxypropyl methylcellulose (HPMC) E5. Solid dispersions were prepared by melting, solvent evaporation & microwave method. The dispersions were evaluated for various in vitro parameters such as solubility study, dissolution study, fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) & scanning electron microscopy (SEM). Solubility & dissolution rate of CC was significantly higher in microwave assisted solid dispersions in comparison with pure drug, melting & solvent evaporation generated solid dispersions. Results of DSC, XRD and SEM study showed transformation of crystalline form of CC to amorphous form in microwave assisted solid dispersions. Thus, microwave technology offers a simple, efficient, solvent free promising alternative method to prepare solid dispersion of CC with significant enhancement of the solubility & dissolution rate. Keywords: Microwave, candesartan cilexetil, solubility, dissolution rate
Pubblicato
Fascicolo
Sezione
Licenza
Declaration and Copyright Transfer Form
(to be completed by authors)
I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.
· I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
· I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
· I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
· I/We also agree to the authorship of the article in the following order:
Author’s name
1. ________________
2. ________________
3. ________________
_______________
We Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal. |
