Protective Effect of Epigallocatechin Gallate (EGCG) on Sodium Fluoride (NaF) Induced Changes in Histology of Selected Organs in Rats

Forfattere

  • S Thangapandiyan Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India
  • S Milton prabu Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India

Nøgleord:

Histopathology, EGCG, NaF, oxidative stress, ROS, histology

Resumé

Histopathology is the microscopical examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail. The present study, has been designed to evaluate the effects of oral administration of Sodium Fluoride (NaF) 25 mg/kg/bw (orally), NaF with EGCG (40 mg/kg/bw) daily for four weeks on histological alterations, if any on heart, liver, kidney and testes of rats. Rats were weighed about 160–180 g. NaF alone treated groups showed marked inflammation, necrosis and degenerative changes in the heart, kidney, liver and testes. Treatement with EGCG showed marked improvement in all the degenerative changes inflicted by NaF. Thus, the result of the present study clearly demonstrated that the EGCG due to its free radical scavenging and antioxidant activity, it protects against NaF induced oxidative histopathological changes in the heart, liver, kidney and testes.

Forfatterbiografi

  • S Milton prabu, Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India
    Assistant professor, Depratment of zoology, Annamalai university.

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Publiceret

2013-05-08

Nummer

Årg. 3 Nr. 1 (2013)

Sektion

Research Articles

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