Experimental Study on Cyanoacrylate as Wound Adhesive

Autor/innen

  • Sohayla M. Attalla Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine-Mansoura University, Egypt
  • Wageih M. Ghanam Department of Surgery, Faculty of Medicine-Mansoura University, Egypt
  • Ibraheim M. El-Shawaf Department of and Pathology, Faculty of Medicine-Mansoura University, Egypt
  • Osama Shabka Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine-Mansoura University, Egypt
  • Mohamed Salama Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine-Mansoura University, Egypt

Schlagwörter:

CAs, toxicity, medical glues, biocompatibility

Abstract

Cyanoacrylates (CAs) have been widely used as surgical glues; however, the high cost of medical CA-based glues limits their use in developing countries. Another possible alternative is the low cost α-CAs which are normally used in commercial glues. The lack of toxicity studies of such agents is considered the main obstacle in their medical application. In the present study, we have evaluated the toxicity profile of commercial glue in comparison to medical octyl cyanoacrylates (OCAs) in rats. In the studied groups, α-CAs revealed to be safe with comparable bio-compatibility and wound healing effects to medically used OCAs. These results advocate the possible substitution of the high-cost medical glues with the low-cost commercial ones without the hazards of toxicity.

Downloads

Veröffentlicht

2012-06-15

Ausgabe

Bd. 2 Nr. 1 (2012)

Rubrik

Research Articles

Lizenz

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.