Protective Effect of Epigallocatechin Gallate (EGCG) on Sodium Fluoride (NaF) Induced Changes in Histology of Selected Organs in Rats

Auteurs-es

  • S Thangapandiyan Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India
  • S Milton prabu Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India

Mots-clés :

Histopathology, EGCG, NaF, oxidative stress, ROS, histology

Résumé

Histopathology is the microscopical examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail. The present study, has been designed to evaluate the effects of oral administration of Sodium Fluoride (NaF) 25 mg/kg/bw (orally), NaF with EGCG (40 mg/kg/bw) daily for four weeks on histological alterations, if any on heart, liver, kidney and testes of rats. Rats were weighed about 160–180 g. NaF alone treated groups showed marked inflammation, necrosis and degenerative changes in the heart, kidney, liver and testes. Treatement with EGCG showed marked improvement in all the degenerative changes inflicted by NaF. Thus, the result of the present study clearly demonstrated that the EGCG due to its free radical scavenging and antioxidant activity, it protects against NaF induced oxidative histopathological changes in the heart, liver, kidney and testes.

Biographie de l'auteur-e

  • S Milton prabu, Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, India
    Assistant professor, Depratment of zoology, Annamalai university.

Téléchargements

Fichiers supplémentaires

Publié

2013-05-08

Numéro

Vol. 3 No. 1 (2013)

Rubrique

Research Articles

Licence

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.