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Chitosan-Glycine Cross-Linked Microspheres for Controlled Release of Isoniazid

K. C. Gupta, M NV Ravikumar, Fawzi Habeeb Jabrail


Semi-interpenetrating polymer network microspheres of chitosan with glycine have been prepared for encapsulation and controlled release of isoniazid (INH) as a model drug. The method involved the exposure of microspheres to the vapor of cross-linking agent to effect the cross-linking under mild conditions. The swelling behavior, hydrolytic degradation and loading capacity of microspheres for INH have been investigated. The prepared microspheres have shown 96% drug loading capacity, which suggested that these semi-interpenetrating polymer network microspheres are suitable to controlled release of drugs in an oral sustained delivery system.

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K. C. Gupta, M. N. V. Ravikumar, Fawzi Habeeb Jabrail. Chitosan-Glycine Cross-Linked microspheres for controlled release of isoniazid. Journal of Modern Chemistry & Chemical Technology. 2015; 6(3): 7–12p.


Polymer, microspheres, glycine, cross-linking, drugs

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