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Antibacterial Activity of CaSO4 Nanorods Prepared via Hydrothermal Method Compared to Bulk CaSO4

Durga Prasad, H. Nagabhushana, C. R. Girija, T. V. Venkatesha, B. M. Nagabhushana



Calcium sulphate (CaSO4) nanorods have been synthesized by low-temperature hydrothermal method using CaSO4 powder as precursor and hexadecylamine (HDA) as surfactant at 180 0C for 7 days. The powder X-ray diffraction (PXRD) patterns were studied. Scanning electron microscopy (SEM) images show nanorods have diameters of about 100nm-200nm and length of about 2-10μm. Fourier transformed infrared spectrum (FTIR) shows a strong doublet is observed near 609 and 681cm-1 due to the ν4 (SO42-) bending vibrations. A strongest band observed at 1132 cm-1 is due to ν3 (SO42-) stretching vibration. A clinical isolate of E Coli, S. aureus was used as the test strain, In the presence of sub-inhibitory concentration of CaSO4 nanoparticles. The nanomaterial showed an effective inhibitory effect against E. coli at different concentration of CaSO4 which was done by disc diffusion method. The antibacterial property of the material seems to arise due to changes in the microenvironment in the vicinity of organism-particle contact area causing damage to the cell membranes on intimate contact between the cell and particle. It is observed that the antibacterial activity of CaSo4 nanorods compound with bulk CaSO4 Since CaSO4 nano particles were found to be more abrasive than bulk CaSO4



Hydrothermal, CaSO4 nanorods, FTIR, antimicrobial activity, SEM, E. coli

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