Stem Cell Delivery Methods: Opportunities and Challenges

Abstract

There are many approaches to cell delivery, each with its own unique aspect and subtle pros and cons. Instead of solely looking at the objective results, the efficacy of these delivery systems should be evaluated on a case-by-case basis. Optimal cell therapy depends on successful delivery into the area of need, engraftment of a sufficient concentration of cells and prolonged survival of the transplanted cells. While cells have been delivered and a biological effect has been observed, the optimal stem/precursor cell to use, the number of cells required, the timing of transplantation post-infarction, and the optimal cellular milieu and delivery route have yet to be determined.

Keywords: Stem cell delivery, self-renewal, survival